The high-throughput screening technology developed by Zacharon Pharmaceuticals can be applied to identify and develop small molecule drugs across a variety of glycan classes with a range of therapeutic applications. Zacharon is initially focusing its research and development activities in the following areas:
Glycosaminoglycans are linear glycans that contain alternating amino sugars and uronic acids. Drugs targeting glycosaminoglycans have many potential therapeutic uses including inhibition of tumor growth and angiogenesis, repair of spinal cord injuries, and lysosomal storage diseases [1-4]. For additional information related to Zacharonís therapeutic strategy in lysosomal storage disease, please click here.
Several classes of O-linked glycans exist, the classical type containing a glycan attached to proteins via a-N-acetylgalactosamine to the hydroxyl group of serine/threonine side chains. Drugs targeting O-linked glycans have strong promise as therapeutics for treating various forms of cancer and inflammation [1, 5-11]
Gangliosides (GSLs) are compounds composed of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acids (AKA n-acetylneuraminic acid, NANA) linked on the sugar chain. The role of GSLs in the pathogenesis of cancer and lipid storage diseases has been well-documented, making GSLs a compelling therapeutic target [12-17].
Many glycoproteins contain glycans linked through a glycosylamine bond to asparagines residues. These N-Linked glycans play central roles in protein quality control with the endoplasmic reticulum and Golgi. N-linked glycans have been implicated in cancer and other diseases [2, 18].
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